New to APOE4?
That’s exactly why I created APOE44.org - a free educational resource to help you understand APOE4, brain health, and prevention strategies without having to sort through thousands of research papers on your own.
For those looking for a more structured roadmap, I’ve also created the APOE4 Prevention Blueprint at Members.APOE44.org, where I’ve organized the tools, lab tracking, prevention modules, and practical resources I’ve developed over the years.
Not sure of your APOE status? If you’ve tested with 23andMe, AncestryDNA, MyHeritage, or another DNA service and have access to your raw data, your APOE genotype is determined by two SNPs: rs429358 and rs7412. The combinations below show how those results translate into APOE2, APOE3, and APOE4 genotypes.
Which APOE gene alleles determine the variant? Here are the possibilities:
Common Genotype Combinations (Unphased Raw Data)
rs429358 T/T + rs7412 T/T → APOE 2/2
rs429358 T/T + rs7412 T/C → APOE 2/3
rs429358 T/T + rs7412 C/C → APOE 3/3
rs429358 T/C + rs7412 T/C → APOE 2/4
rs429358 T/C + rs7412 C/C → APOE 3/4
rs429358 C/C + rs7412 C/C → APOE 4/4
About me
Today, at age 73, I’ve already passed the average age at which symptoms often begin to appear in APOE4/4 carriers - and I remain physically active, cognitively engaged, and optimistic about the future.
What began as fear and panic quickly gave way to resolve - and something deeper: a calling.
As a successful entrepreneur and business owner, I’ve spent my life in productive action - and this was no different. I dove headfirst into everything I could find about APOE4: the science, the protocols, the stories, and the strategies. I wasn’t about to hand over my future to fear.
Now, I want to share what I’ve learned - to empower and offer hope to my fellow APOE4/4 sisters and brothers. I’ve even come to embrace these genes. They’ve served me well in life. And the truth is, we all carry risk genes - whether for Alzheimer’s, breast cancer, ALS, or something else. The key is, knowing what risks might be wired into our genes, and what we do with that knowledge to counteract that risk.
My theory is simple: Alzheimer’s is a disease of aging. APOE4 is not a deterministic gene. Starting as early as our 20s, 30s, and 40s, the body’s ability to maintain optimal health begins to decline. Cellular senescence sets in, hormones start to wane, nutrient absorption becomes less efficient, and the wear and tear from long-standing habits begins to show.
But if we can counter these changes and actively support the body's resilience, we don't just delay Alzheimer's - we may be able to reduce risk dramatically and perhaps prevent many cases altogether.
If the APOE4 gene affects you or someone you love, I’d be honored to have you subscribe and join this journey with me.
p.s. For quick takes and live updates, check out my Notes too!
