Brilliant work linking membrane fluidity to ABCA1 function. The idea that cholesterol efflux isn't just about transporter expresion but about the membrane environment those transporters sit in is honestly something I needed to hear more clearly. I've been focused on optimizing omega-3s for months but never really thought through phosphatidylcholine as the literal foundation. The pulsing approach you describe makes way more sense than trying to supplement every single day.
Karen, great read! I have a few questions as I'm taking very similar Omega's as you and also eat salmon 2-3x/week.
Is there any data that going off/on with your Bio Body and Prodrome is better than continual? I've been doing it daily (along with a Nordic Naturals phospholipid Omega 3) but keep wondering if my blood is getting too thin.
I take 2 Bio Body phospholipid cholines and 2 Prodrome Neuro per day staggered along with the Nordic Naturals. Why do you take Glia Also?
Hi Doug, Personally, I cycle primarily to avoid overdoing any one pathway and to periodically reassess how I feel and just give my body a reset break.
On blood thinning: phospholipid omega-3s and DHA/EPA can have mild anti-platelet effects, but in people without bleeding issues or anticoagulant use, this is usually modest. I don’t worry about it unless there are signs like easy bruising, nosebleeds which I haven't had. Eating salmon or sardines 2–3x/week plus supplements is still generally within a reasonable range, but it’s smart that you’re thinking about total exposure. As for Prodrome Glia: I use it because neuronal health isn’t just about neurons. Glial cells regulate inflammation, synaptic support, lipid handling, and repair, which becomes more relevant with age and APOE-related risk. Neuro supports neurons; Glia supports the environment they live in. I don’t take Glia constantly either - more as a cycled strategic add-in. Thanks for the kind words - and great questions.
Very interesting stuff! I don't have the background to evaluate it, but you lay out what sounds to me like a reasoned case. And thank you for sharing your observations so generously.
I went off and did a brief search on phosphatidylcholine and found the article at the attached link, which suggests increased all-cause and CVD mortality in those who got more phosphatidylcholine from their diet (red meat, eggs, fish) vs less. It's an observational study. My first thought is what else is correlated with that diet that could contribute to mortality. Wonder what you make of it?
I saw that when I was researching this post. (initially I thought I posted a wrong reference link!). That study discusses phosphatidylcholine largely in the context of a proposed TMAO pathway, but it doesn’t directly measure TMAO. We now know TMAO production varies widely based on the gut microbiome and metabolic health, and it isn’t uniformly associated with harm - fish, for example, is high in TMAO yet consistently linked to lower cardiovascular risk. I believe the findings are better interpreted as dietary pattern associations rather than evidence of direct causality.
Brilliant work linking membrane fluidity to ABCA1 function. The idea that cholesterol efflux isn't just about transporter expresion but about the membrane environment those transporters sit in is honestly something I needed to hear more clearly. I've been focused on optimizing omega-3s for months but never really thought through phosphatidylcholine as the literal foundation. The pulsing approach you describe makes way more sense than trying to supplement every single day.
Karen, great read! I have a few questions as I'm taking very similar Omega's as you and also eat salmon 2-3x/week.
Is there any data that going off/on with your Bio Body and Prodrome is better than continual? I've been doing it daily (along with a Nordic Naturals phospholipid Omega 3) but keep wondering if my blood is getting too thin.
I take 2 Bio Body phospholipid cholines and 2 Prodrome Neuro per day staggered along with the Nordic Naturals. Why do you take Glia Also?
Thanks so much and keep up the good work!!!
Hi Doug, Personally, I cycle primarily to avoid overdoing any one pathway and to periodically reassess how I feel and just give my body a reset break.
On blood thinning: phospholipid omega-3s and DHA/EPA can have mild anti-platelet effects, but in people without bleeding issues or anticoagulant use, this is usually modest. I don’t worry about it unless there are signs like easy bruising, nosebleeds which I haven't had. Eating salmon or sardines 2–3x/week plus supplements is still generally within a reasonable range, but it’s smart that you’re thinking about total exposure. As for Prodrome Glia: I use it because neuronal health isn’t just about neurons. Glial cells regulate inflammation, synaptic support, lipid handling, and repair, which becomes more relevant with age and APOE-related risk. Neuro supports neurons; Glia supports the environment they live in. I don’t take Glia constantly either - more as a cycled strategic add-in. Thanks for the kind words - and great questions.
Very interesting stuff! I don't have the background to evaluate it, but you lay out what sounds to me like a reasoned case. And thank you for sharing your observations so generously.
I went off and did a brief search on phosphatidylcholine and found the article at the attached link, which suggests increased all-cause and CVD mortality in those who got more phosphatidylcholine from their diet (red meat, eggs, fish) vs less. It's an observational study. My first thought is what else is correlated with that diet that could contribute to mortality. Wonder what you make of it?
https://pmc.ncbi.nlm.nih.gov/articles/PMC4919531/
I saw that when I was researching this post. (initially I thought I posted a wrong reference link!). That study discusses phosphatidylcholine largely in the context of a proposed TMAO pathway, but it doesn’t directly measure TMAO. We now know TMAO production varies widely based on the gut microbiome and metabolic health, and it isn’t uniformly associated with harm - fish, for example, is high in TMAO yet consistently linked to lower cardiovascular risk. I believe the findings are better interpreted as dietary pattern associations rather than evidence of direct causality.
Thanks. They do posit TMAO as a mechanism, but as you say, there's no direct measurement, so who knows? And your logic about fish makes sense.