So interesting, thanks Karin! Love the way you always build in a practical approach. I also had low Akkermansia and found the Timeline Urolithin A a gam changer. My gut is far more resilient and settled than it was. Immune reactions to foods have gone down and I’m able to eat more widely. The background low grade discomfort has resolved. I took it for about 6 months and have now swapped over to pendulum Akkermnsia but it was the Urolithin A that made the big difference in building up Akkermansia.
"This matters for APOE4 because bile acids are not just digestive detergents - they are signaling molecules that influence metabolic tone, inflammatory pathways, and gut microbial balance. When bile flow is sluggish or bile signaling is disrupted, downstream effects can include dysbiosis, impaired lipid handling, and increased inflammatory burden"
Great article Karin! Well written.
I did not know the extent that bile acids played a role in influencing the gut microbiome and changes in lipid handling beyond inflammation in Acute Pancreatitis (AP).
Do you think that modulating the gut microbiome might help guard against the risk of developing AP?
I have not heard of too much research looking at the gut microbiome and calcium signalling in the pancreas but wonder if there is a link there.
That’s a interesting question but honestly, acute pancreatitis isn’t an area I’ve dug into. My focus has mostly been on bile acids in the context of metabolic signaling and APOE4-related brain risk. Whether actively modulating the microbiome reduces AP risk is something I’m not familiar enough with to answer.
Another great article with specific actions I can start today! Thank you!!
Thank you for the post!🙌
So interesting, thanks Karin! Love the way you always build in a practical approach. I also had low Akkermansia and found the Timeline Urolithin A a gam changer. My gut is far more resilient and settled than it was. Immune reactions to foods have gone down and I’m able to eat more widely. The background low grade discomfort has resolved. I took it for about 6 months and have now swapped over to pendulum Akkermnsia but it was the Urolithin A that made the big difference in building up Akkermansia.
"This matters for APOE4 because bile acids are not just digestive detergents - they are signaling molecules that influence metabolic tone, inflammatory pathways, and gut microbial balance. When bile flow is sluggish or bile signaling is disrupted, downstream effects can include dysbiosis, impaired lipid handling, and increased inflammatory burden"
Great article Karin! Well written.
I did not know the extent that bile acids played a role in influencing the gut microbiome and changes in lipid handling beyond inflammation in Acute Pancreatitis (AP).
Do you think that modulating the gut microbiome might help guard against the risk of developing AP?
I have not heard of too much research looking at the gut microbiome and calcium signalling in the pancreas but wonder if there is a link there.
What are your thoughts?
That’s a interesting question but honestly, acute pancreatitis isn’t an area I’ve dug into. My focus has mostly been on bile acids in the context of metabolic signaling and APOE4-related brain risk. Whether actively modulating the microbiome reduces AP risk is something I’m not familiar enough with to answer.