Thank you. This is certainly food for thought, on multiple levels.
Going beyond Alzheimers's for a moment, a quick look at the literature on palmitoylethanolamide (PEA) shows that it can be useful for a range of sources of discomfort. That might be useful for people who lack the ability to express any details of their apparent pain.
Consider people with what is now referred to as severe or profound autism. For some of them it appears that uncommunicated somatic pain may be at the root of some very disturbing behaviors. The medical field has no way to deal with that. There is some research into mast cells etc. but this can go deeper. Maybe...
Thank you for this lovely article. It inspired me to dig further into the use of PEA and luteolin for people with atopic conditions where mast cell degranulation is part of the whole inflammatory pathway.
If we replace microglia in the brain w macrophages, eosinophils and dendritic cells, the pathway for inflammation in the skin, lungs and nasal mucosa are similar to what you describe for the brain. 💪
As a biomedical student, I agree with you. I actually think targeting amyloid might actually be unnecessary, because, from what I have read those foam cells and lipid overloading you mentioned impair waste removal, and amyloid and tau tangles are essentially waste products that impair lysosomal function. By helping to get rid of the lipid droplets, it may be that the brain itself is able remove the plaques and tangles.
Thank you. This is certainly food for thought, on multiple levels.
Going beyond Alzheimers's for a moment, a quick look at the literature on palmitoylethanolamide (PEA) shows that it can be useful for a range of sources of discomfort. That might be useful for people who lack the ability to express any details of their apparent pain.
Consider people with what is now referred to as severe or profound autism. For some of them it appears that uncommunicated somatic pain may be at the root of some very disturbing behaviors. The medical field has no way to deal with that. There is some research into mast cells etc. but this can go deeper. Maybe...
Thank you for this lovely article. It inspired me to dig further into the use of PEA and luteolin for people with atopic conditions where mast cell degranulation is part of the whole inflammatory pathway.
If we replace microglia in the brain w macrophages, eosinophils and dendritic cells, the pathway for inflammation in the skin, lungs and nasal mucosa are similar to what you describe for the brain. 💪
As a biomedical student, I agree with you. I actually think targeting amyloid might actually be unnecessary, because, from what I have read those foam cells and lipid overloading you mentioned impair waste removal, and amyloid and tau tangles are essentially waste products that impair lysosomal function. By helping to get rid of the lipid droplets, it may be that the brain itself is able remove the plaques and tangles.