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CB's avatar

Well done thanks . When brain derived ptau217 (bd ptau217 ) moves out of research use the numbers will get sharper but the take home of change being possible is key.

Nancy J Hess's avatar

So clear and accessible. Your work is extraordinary. I am learning so much from you.

Sharon Tucker's avatar

Thank you for this. I tried to read and absorb the study with all the graphs and math but that is not something I do well. I appreciate you making it so understandable. This study gives me much hope.

Alexander MacInnis's avatar

Thank you, Karin. Excellent article.

This is something we should bring to our doctors. While they generally read the blue chip medical literature, they might not be so familiar with these points.

cathy bliss's avatar

Karin thank you again for all your research and clear explanations. I took a ptau test through Care Access and I remember that there are two types of ptau testing. I will go find that info.

Linda Marr's avatar

Thank you Karin for your thorough and incredibly well laid out discussion of the testing and what it might mean for us 4/4s. When i think of what my mom went through, i know I want to do everything i can to ward off Alzheimer’s And thank you Karen for you helpful info as well.

Karen Kroupa's avatar

I hadn't seen the July JAMA article but will certainly check it out. Is the Washington University "clock" openly available? That would be interesting to check out. After a recent emergency appendectomy I was really concerned about my gut biome being destroyed by the antibiotics (I had no prior medical history) and what my post recovery efforts should be to get my biomarkers back into the optimal zone. So I dumped 8 years worth of data - bloodwork, scans, images, cognitive testing, medical history, genetics, research study participation, family history, etc into AI and generated an actuarial level projection of risk for remaining cognitively normal for the next 2 decades (I'm 65 now). It produced a 66 page report with a short, intermediate, and long term action plan as well as suggestions for ongoing monitoring. I titled it Risk and Resilience Coexist. Ptau217 is modifiable. As a 4/4 anything that's modifiable is a win in my opinion! Thanks for another great article with actionable information!